If you have a problem where your nerves cause pain or numbness, called peripheral neuropathy.If you have been told you have anaemia, or if you have low levels of vitamin B or folic acid.If you have diabetes (diabetes mellitus).If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work.Although nitrofurantoin can be taken during pregnancy, it is still important that you tell your doctor about being pregnant. For these reasons, before you start taking nitrofurantoin it is important that your doctor knows: 2007 176(3):319-320.Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken.
Acute respiratory failure during pregnancy: a case of nitrofurantoin-induced pneumonitis. Urinary tract infections during pregnancy.
The safety of nitrofurantoin during the first trimester of pregnancy: meta-analysis. Ben David S, Einarson T, Ben David Y, et al.Hemolytic reactions to nitrofurantoin in patients with glucose-6-phosphate dehydrogenase deficiency: theory and practice. General reproduction, perinatal-postnatal, and teratology studies of nitrofurantoin macrocrystals in rats and rabbits. Sulfonamides, nitrofurantoin, and risk of birth defects. American College of Obstetricians and Gynecologists.Neonatal outcomes after gestational exposure to nitrofurantoin. Nordeng H, Lupattelli A, Romøren M, Koren G.Furadantin (nitrofurantoin) oral suspension.Drug experts seem to disagree with nitrofurantoin’s prescribing information, but as always, each patient scenario must be viewed independently, and all risks and benefits must be weighed. This statement was derived from the generally mixed evidence concerning an association between nitrofurantoin and birth defects. However, the American College of Obstetricians and Gynecologists Committee Opinion on sulfonamides, nitrofurantoin, and risk of birth defects state that if other treatment options are not able to be used (eg, cephalosporins, erythromycin), then sulfonamides and nitrofurantoin may be used as first-line agents for the treatment of UTI during the second and third trimesters. In isolation, this study would suggest that nitrofurantoin should be avoided in the last 30 days of pregnancy. While no neonates in the registry were identified as having glucose-6-phosphate dehydrogenase deficiency, there was no difference in the incidence of hemolytic anemia. It is important to note that the difference in incidence of neonatal jaundice did not affect pregnancy outcomes in the study population. This significant difference held up after multivariate analysis that adjusted for prematurity, neonatal sex, year of birth, use of oxytocin to induce labor, neonatal systemic antibiotic treatment, maternal age, parity, and smoking at the end of pregnancy. However, neonates exposed to nitrofurantoin in the last 30 days before delivery had a significantly higher rate of neonatal jaundice requiring treatment compared with neonates exposed to pivmecillinam during the same stage of pregnancy (10.8% and 8.8%, respectively p=0.023). Moreover, the rates of negative pregnancy outcomes such as stillbirth and neonatal mortality, low birth weight, preterm delivery, transfer to NICU, or Apgar score lower than 7 at 5 minutes were no different among the study groups. After comparing 1334 mothers who received nitrofurantoin during their pregnancy with 5800 mothers who received pivmecillinam and 130,889 mothers who received no antibiotics for UTIs, the researchers found that the incidence of any malformation-including cardiovascular, atrial septum, or ventricular septum defects-were no different among the groups.
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